First issue: V.A.T.S cancellation. The player should be able to cancel V.A.T.S anytime they want in action. I had the worst problem in hardcoe mode about dying in V.A.T.S when against tough enemies like the poisonous enemies, group of faction enemies and other ones. I also had problems with lever action weapons (cowboy rifle, lever action shotgun, trail carbine etc) Not shooting while in V.A.T.S
Second issue: NPC's not working as well as weapons doing nothing. I thought of this during when I was fighting legion assasins, but they wouldn't attack and they wouldn't move as soon as they become hostile. So I thought of the "Reload Game" button. The buttons reloads the game and everything around, as the map and the NPC's will reload and have the normal and hostile move against you. And the game reloads where you are, and changes nothing that happens except anything broken.