It's good to see that some people are looking beyond the obvious black-and-white Railroad Vs Institute situation and references to past films and novels; hopefully BGS have done the same.
I would like the Railroad/Institute story not to be the focus of the main quest, but rather a major side-quest like the Skyrim civil war. And as with that scenario, have no clearly defined "right" or "wrong" decision, just a choice based on in-game experience and personal opinion. Add in the simple possibility that the PC may be an android (something that would never be actually confirmed or denied), and there is scope for some great stories genuinely difficult decision-making.
As for the physical appearance of the androids, I suspect we'll see various "generations", with older versions relegated to menial tasks and not "maintained" (i.e. they would be obviously not human and may have visible defects, like the guy in the trailer). I wonder if we might even see some very early attempts, say using adapted Power Armor suits as the "body".