The topic was Skyrim being “soulless”.
http://www.gamesas.com/index.php?/topic/1309579-skyrim-is-soulless/
Take the starting town of NV as an example. I can remember very clearly (and it's been a long time since I played that game) most of the NPCs there, due to their distinct personalities.
The doctor who had lost his wife. I managed to sweet talk him in to giving me extra medical supplies (a use of the speech skill that actually mattered and had some effect).
The hunter who taught me how to shoot and cook. She had a dog, it died while we were saving another woman from some Geckos, and she was devastated.
The old guy who liked to sit on the porch of the bar. He used to be a treasure hunter, and he didn't trust me enough to give me some explosives. Again, a speech test that mattered.
The bar owner. She had a broken radio. I had the option to be a complete dike to her when she started talking about it rather than the info I was after.
The shop keeper who cared more about his own safety than anything else.
The cowboy robot?
And there were MORE. Each with tons of dialogue.
Almost immediately there was the option of helping these people, forever becoming a hero to them (and it was reflected in what they said). Or siding with a gang of escaped convicts to wipe the town out, an act that would put me in good with their faction for later.
Fallout 3. Megaton. Even longer since I played.
The Sheriff. I killed him, stole his clothes, and lived in his house. His kid used to come down while I was sat at the table and say “You'll never be my father!” with real hatred in his voice. The rest of the town called me “Sheriff”.
The woman who wanted you help write her book. She was overly cheerful in a crazed kind of way, especially when sending you in to danger.
The ghoul bartender, the prosttute with attitude, the shady bar-owner, the guy wanting you to help nuke the place...EVERYONE in the bar. All memorable.
You could literally wipe the town off of the map.
Let's compare that with Whiterun. Sure, I know the NPCs, but only because I've seen them so often. I've talked to them, most only have one liners but a few did offer me some backstory. I've had no real interaction with the majority of them. What can I tell you about the battle-borns, one of the major families of the town? One has a moustache, and one likes to lean against buildings. I took out the Jarl in single combat, putting someone else on the throne...noone cared.
The NPCs in places like Rorikstead, I can't really recall at all, except in a blurry kind of way. One guy was the owner and...nope, that's it.
The only NPCs I've encountered who I really liked have been the Dark Brotherhood. All good, strongly written memorable characters. The moment you walk in on them for the first time and they're swapping stories was fantastic. They all have lots of dialogue updates depending on which stage of the quests you're on. Cicero is the man. Fact.
I don't expect every single NPC to be so finely detailed, but I don't think a few in each hold would be too much to ask. Those saying “TES has NEVER been like that!!11”. Well, maybe not. But this isn't whatever-year-it-was Daggerfall came out. Improvements are to be expected.
For the record, I love Skyrim. But let's all be honest about its flaws.