Some of the new things I love, others...not so much, if at all.
I love the new crafting system, but hate the UI as a PC user. The UI is clunky, and not at all m/k friendly. Don't think I've ever come across a game, that ask the user to implement WASD, arrow keys and E + enter in the same menus. It is weird, and not really intuitive in any way.
As for the perks/skill system, I'm in two minds here. The previous skill system wasn't optimal, but neither is the new one. I can't build a really sneaky character from the get go, because the ranks achievable are gated behind levels. So no very sneaky but awful at combat from the get go. It makes for a more rounded character, without to many quirks....but I loved those quirks.
Speaking of combat. Combat is now decided, more or less, how good at FPS games you are, since VATS doesn't stop time anymore, and you can only crit in VATS which is now clunky because you have to rush decision where to hit, and try to hit crit and E to resolve. It makes for [censored] Fallout combat. To be honest, if I wanted to play a straigth up shooter, Fallout wouldn't be my choice. As a sidenote, which probably will get fixed by mods, with so much emphasise on direct FPS shooting, why the heck isn't there more options of crosshairs? The default ingame, is bad. The AI is absolutely better tho, altho I will hope there comes a mod, so all raiders doesn't have 3+ molov's on them
Dialogue wheel along with voiced character? I simply can't fathom this decision. My character will sound the same for every playthrough, so there goes immersion, along with always being Mr.Goodguy with the same basic motivation to wander in the first place. So, likely I will play through it as male and female, and then time will tell if I can stomach more. Dialogue wheel is horrible. More often than not, I can't predict what my character will say, and if that is what I had in mind. It is severely limiting in the RPG factor. Most NPC and including the sound of my character, are very bland, and makes for a sort of sterile feel. Think it has to do with a combination of poor execution and trying to make one shoe fit all kinda thing. It just feels off.
The world (what I have seen so far with 25 hours under the hood) is nice enough, altho the textures is not that good. I can forgive that, since it shouldn't be that important for a game like this. The colour schemes however. It is really wayyyy to bright, even with godrays on low. I had to lower it on my monitor, else it gave me headaches with bright lights all over the place (surely there will come mod's for this, but still) And the headbopping, please make it stop!
As for degradation of gear, I'm indifferent to it. I didn't mind the struggle to keep my weapons up to par and manage inventory via combining armour and weapons. I don't mind it is gone since there is a better crafting system in place. However, I do dislike the removal on making ammo myself. I don't struggle at all right now with ammo, since it is all over the place (imo) but I wish I would!
Overall I like the game, but there are some serious thorns, which will probably lower my amounts of playtroughs to one male and one female playthrough, since any others after that, will be with the same person, with the same motivations.