Correct me if I'm wrong, but isn't modding for Skyrim limited by the Creation Engine's tendency to crash when more than 3.1GB memory is used?
http://forums.nexusmods.com/index.php?/topic/1033442-skyrim-31gb-crash-limit-skyrim-performance-monitor/page-4
It would really be a shame if this limit applies to FO4, limiting the amount of mods that one can have running (especially hi-res texture mods).
Any thoughts?