Based on this, here is what I'm led to conclude:
The player is 'strongly' discouraged from going in certain directions in the game world, most notably north and west of Goodsprings owing to the abundance of powerful critters, but also as a result of how the landscape is modeled. There are quite a few ridges that you can get right to the crest of, but cannot actually cross onto the top of, the intent here seemingly is to funnel the player to access certain areas through their proper 'entry points' and not from multiple different directions.
I'm loving the game and it is a masterpiece. But this dynamic just feels less 'open' to me than FO3 did, and thus more frustrating and less satisfying.
The game seems to want the player to follow these steps and the combination of boundaries/obstacles in the landscape and the structuring of quests really does a pretty good job of accomplishing it as far as I can tell:
1. Visit Primm &/or NCRCF
2. Do not go straight North
3. Visit Nipton &/or Mojave Outpost
4. Visit Novac
Am I wrong here? Missing something? Should I play on with particular goals/trajectories more in mind?