1) Fallout New Vegas is still not fully Quad Processor supported (Just like Fallout 3). This issue was causing random CTD's on my system. Installed .ini work around. CTD's gone.
bUseThreadedAI=1
iNumHWThreads=2
2) Fallout New Vegas is even more sensitive to non-windows codecs than fallout 3 was. This issue was causing random freezes on my system. Removed all non-windows codecs from my system. Freezes gone.
System:
Intel Quad Core Q660 2.4Ghz
2GB RAM
500 GB Western Digital HD
Realtek on-board sound (2.54 drivers)
Nvidia 250 GTS 1GB (260.99 driver)
Windows XP SP3
Direct X 9.0c