I got the FO:NV Ultimate Edition for PS3.

I've played the game for who knows how many, many, many hours. I was playing Crimson Caravan Company mission. The game freezed, and when I try to run it now, it won't start.

It loads for a while, but then stops and the screen is left black. Pressing buttons on controlled doesn't help. It's simply freezed!

Is there any way to salvage the game anymore? Or is it now locked?

Revert to an earlier save.

Uninstall and reinstall your game (this won't affect your savefiles.)

By chance did you mod your game in any way?

I haven't MODded it. Thanks for the tip, I'll try it.