The only thing I've been able to do is turn off all autosave options, and turn down the music. If you've already done this, then I'm not sure what you can do. This only helps though, I still freeze every now and then, just less often than before.
I have no idea how the filesize works. Mine fluctuates every day, whether I finish long quests, or just go sell a few items it can go up or down by 500kb.