There are a number of mods out there addressing autoaim, and a few of them have authors that claim to have initially tried completely disabling auto-aim, only to fine that the projectile then fired in the direction that the gun model was pointing, rather than at the crosshair. I'm trying to figure out how they did that, because it's exactly what you want if you want to aim with laser sights, like the ones in Weapon Mod Kits. It would look cool, work as a perfect auto aim disabler, plus if you're using nVidia's 3D Vision, the default crosshair is worthless, while a laser sight would work great.

Never mind, there's an explanation in Bethesda's GECK wiki. Set fAutoAimMaxDegrees to 0.