So, I see 2 possibilities to enhance my F3 experience:
Mods or some ideas from the Fallout hardcoe thread...
Thanks for the Sniper Rifle info.
Enhancing my game experience I did by keeping to modest weapons and armour, not using Stimpacks (not during battle, but to save a trek back to some bed, I did on a rare occasion use some) or chem enhancements and having no companion, didn't use VATS either (occasionally to identify an enemy red dot). I was hesitant about dropping VATS at first, but I soon found it normal and actually more fun and for real.
The time when VATS would have made it a lot easier is when jumped on by a group of Mercenaries, but it turned out not to be a problem really, just don't stand still and make use of doors. Anyway the game remained a consistent degree of challenge on very hard and with a low Endurance of 3 or 4, 3 would be best but care is needed for the first level (I suppose you could Stimpack that bit).
More fun than otherwise for me and not so difficult as to take any fun out of the game. Used quite a lot of tactical play, reducing the numbers one by one. Weapons, Hunting Rifle, Combat Shotgun, Silenced pistol, Scoped Magnum, Grenades, Mines, Bazooka. Assault Rifles I sold/traded to anybody who I could.
I have tried out some of the other weapons when I take them off those I've killed, or found, no need to get too rigid about the rules.
Lincoln's Repeater, good gun but slow, I preferred the Scoped Magnum quite good as well for a fast snap shot when surprised and I'm not holding a Combat Shotgun.