I really liked how Cass was the daughter of John Cassidy and I hope they follow some kind of tradition of having the Cassidy Dynasty as recurring recruitable NPC's. At the end of New Vegas, if you are male and sided with the NCR, its left ambiguous if she slept with the Courier or a different NCR soldier, but I'm assuming the first one is more likely because of the requirements. I like to think that Cass ended up sleeping with Boone and together, they had one NCR Supersoldier baby, but that might go against Boone's character and dedication to his wife. Anyway, I really want to see the NCR Supersoldier Baby be an ally for the next protagonist, if the game is featured near the Core Region. I'd like to see this character being very vocal in combat, just like Cass and John.

If the next game features the Institute, I would like to see Dr. Zimmer's child as the new head of the Synth Retention Bureau.