I think a Fallout that revolves around the concept of freedom would be very nice. South Dakota is untouched and could provide a good origin for this (along with the fact that rural areas in America are mostly avoided by games in general - which gives it kind of an inherent interestingness).
Here's a little excerpt, an impression of South Dakota, 2280:
AMDI sat bored on the terrace of the Catron Boulevard. The terrace had half melted away in the nuclear war and only where he sat, one had reasonably good view of the crusted surface of a city as there had hardly ever been another. He put the binoculars away and once more began reading the newspaper. The threat of the 'Free Youth' was not banned, kamikaze bombers and small guerrilla squads catched a black eye everywhere in the fight against the mainly from Rapid City (where AMDI had just parked his plump ass) originating elite soldiers of the Union. The center of the triangle was lost.
The main trade routes laid on ice, Prosper had locked itself away and was hardly attainable in any way from the outside. Mission continued trade with the central settlements, even those that the Youth had collared. They tried to master this situation through weakness. Some even spoke of negotiations and 'peace plans', even if the other side clearly would've had a low opinion of such ideas. So there was plenty to do. On the one hand the revolutionaries, which obviously needed to be slaughtered, on the other beasts from the outside world, that already endulged themselves over the battle-ravaged areas and proved a great threat for the people. Even jobs as a spy or even a negotiator he would have accepted, but no.
He was a thug for Turquit. Turquit, he was just a low animal in the hierarchy of this crazy raider city, a nuisance and he also was a bad gambler. And there was almost no one AMDI could have beat, because no one wanted to give Turquit a wipe here. The man was too just and too powerless.
AMDI was conceivably unhappy with his situation. He had scored Turquit's girl - it hadn't been fair, that was true. The girl probably had no more inclination in this since her escape. So he worked his debt off for Turquit. Well not entirely as Turquit even paid him sometimes, sorry buddhist that he was. Often times he could even pay his follerers (or stave them off until next week – Turquit was a silver-tongued bastard).
Too much spare time, but AMDI had his debt to fulfill. He could simply shoot the guy down, secretly of course, and just disappear. Nah, too risky. What if that would get out? For the death of the little fat man someone would want revenge if only because he or she could not recover from a corpse Turquits gambling liabilities. There had to be some way to get out of this ridiculous situation. AMDI was a free man after all.
He took the paper and brought it Toni, then he loitered for one hour at Turquit's, only to be sent back home again. He tried again to repair the radio, to no avail. The newspaper had been three days old. More recent information did not exist here. Tomorrow would come a new stack. The toilet worked brilliantly and as far as he was concerned the sewers of Rapid City still were reasonably functional. You could rinse off after all. He disappeared into the poor bathroom (which proved to be -opposite to the main dwelling- amazingly shabby) and [censored] the toilet seat full. That was stupid, no doubt. He got a rag, wiped away the crap and washed it out with cold water. Hot water did not exist here, let alone disinfectant, as where these stuck-up pricks from Mission dwelled. Who needed something like this? In former times, AMDI had wiped his ass with razor blades. He had already switched to comfortable.