Irritating....My game is consistently crashing after the level defending the city center the one that you get killed use the defib 3 times, then press w to crawl to the evac. ship. Play the cinematic perfectly then crashes as it trying to load the next level....Help. I cannot finish the single player version without it!!! Thanks in advance.....
Intel Q6600 OC to 2.9Ghz, EVGA GTX560ti, 4 gigs of ram, Windows 7 Pro 64 bit.....

have you installed Nvidia Forceware 280.26 WHQL which is the lastest driver, released today, which has a lot of Crysis 2 fixes?
are you overclocking? if so, run at stock for troubleshooting.

Try loading the last checkpoint, or going "Resume"... And close all other programs expect Crysis 2!

Tried both suggestions. Still doing the same thing. Very frustrating....

try boosting GPU volts by 0.05

^what he said, and if not, its your unstable CPU thats the problem. (even though 2.9 is not a high OC) Increase the voltage on the CPU to 1.30