40 hours in here not seeing nasty issues like that yet, knock on wood.
I say that as I recall having constant crash issues in FO3 or FONV after a save became corrupt due to some quest glitch or other factors... there is every
reason to believe same can and will happen here as well, in time. That is why I try to keep fresh saves as backup so I wont' lose more than a couple hours at a time.
That said.... have you done any console trickery? Some console commands in the hands of us who are not devs or with detailed knowledge can lead to corruption issues
in a save.
Have you used any mods? Esp mods can be high risk especially without toolkit out yet, some texture mods can cause issues that don't show up right
away. I always try to use rule of thumb to save a known good point before loading any mod, then test a bit before presuming it will be okay later down the road.
That isn't always the case though , as experience showed in FO3, FONV and Skyrim. Stuff happens.
Can you revert to a earlier save to see if that issue goes away? If so that is a sure sign of some sort of corruption in the other save.
JUst a few ideas, luck.