This same thing has been happening to me since I installed the game yesterday. Play for around 3-10min then crash to desktop with no error message.
OS windows 7 64 bit
-I have updated Nvidia GPU drivers
-Tried windowed mode with borderless
-Reduced all settings to low
-Updated anything else that I thought might need updating including motherboard Bios
Nothing is working...
I am currently trying a reinstall but have a feeling that this is not going to work either. (reinstall did not work )
I opened a ticket with Bethesda support yesterday and received an automatic response which hopefully does not mean that they closed my ticket without looking at it.
I have tried to search for fixes but have found nothing other then updating to patch 1.1.30 which as I understand is on steam now as a default.
This seems to be happening to a few people so hopefully they find a fix soon.