Like the tital says, I ckick Save or Quicksave and it says it is saving but LOAD is still blacked out. If i exit the game i have to start all over. Running WIndows 10

I am having the same issue. I am Running windows 10.

Same issue, windows 10. Had the issue with the fallout4 folder not being in My Games as well.

I am going to try uninstalling the game and reinstalling it.

I tried reinstalling. Doesnt work. The fallout 4 folder still doesnt appear in my games folder in my documents.

I got my game to save. =D I went to the My Games folder right clicked and went to properities. Then Security, Clicked on my Users and made sure they had Full Control, Modify and Write checked. Then i Loaded up Fallout 4. Tried to save, it didnt work. So i went back to the My Games Folder, and Fallout4 was now there. I right clicked and went to properities, and to security and made sure Full Control, Modify, and Write were checked. with that folder too. Then started up the game, Saved and was able to load. Not sure if that will fix your guys problems but that is what i did and my game is finally able to save.

You sir, are my hero.