I'd like to see a long, long stretch of road with old gas stations converted to NCR owned/privately owned trade supply stops, where you could get water and food. Just a thought. If people were to expand upon it and add places like the Hub and Shady Sands that would be up to them. I think it would be neat to just have the road, and a "quest" to follow the caravans back and forth as protection (and you get food and water each time the caravan camps, on top of your final pay) .
At least if we expand backwards west, we know what's there and can stay true to lore with it. Eastwards is kind of iffy in my book, since the Courier is kind of following in the wake of NCR (or so it seems to me) and they really don't know what's over the next ridge.
But just populating the areas that way with flora and fauna is perfectly fine in my book. Ain't no need to over complicate something, just for the sake of a mod.