I play on an HTC One, so with a small screen compared to a tablet. Here's the things that I find cause gameplay issues.
1) Trying to select a room to upgrade and not an individual within that room, whether zoomed slightly in or all the way out continuously selects an individual person.
2) Touching the screen to move around and zooming in and out, if not careful selects an individual, several times have accidently moved a person from 1 room to another. Should make it that you need to select a person before you move him/her.
3) While working on people's weaps/clothes and have others in barracks the cam gets pulled to the barracks to see them running to the back to "get busy", and even when the cam gets pulled to a room incident. It's annoying, I don't need to see it. Maybe just an alarm to alert that there's an incident or the Pipboy giving a thumbs up to indicate the other, then I can scroll out and find the room myself.
4) When people are revived from death (and i've had a couple rooms die before) characters go on coffee breaks instead of remaining in that room. Not an issue if it's just 1 person, but multiples from different rooms becomes a problem (in most cases that'll happen after a deathclaw attack)
Otherwise the game seems to run well on my phone, hasn't crashed, no lags or glitches that I have found.