Not particularly. People point out Skyrim's gay marriage but I actually think that might have required less work. Cuz you didn't have to add gender tags to the NPCs, they were just open to everyone. I never married anyone in Skyrim so I don't know if they ever use any kind of genderizing endearments but they might even have avoided extra VO work. Bethesda doesn't have a good track record when it comes to representation. I actually think CDProjekt might be ahead of the curve here.
Here's hoping some Obsidian rubbed off on them with New Vegas though. Actually more than a little. They could use it in the writing department.