Game runs perfectly fine with no issues like any other time when playing, on exit however, that's a different story. I haven't made in .ini changes or added any crazy mods recently. Just getting crashes on exit and I don't know why. I'm on latest NVIDIA drivers and I'm also verified cache.

i5 4690K
MSI GTX 980Ti
Asus Z97-A
GSkill Ripjaws 16GB
2xSamsung 840 Pro 256GB SSD
1x Samsung 850 EVO 500GB SSD
W10

Edit...just tried again and it even does this by starting up and just exiting the main menu without even playing. Have task manager open on my other monitor and the NV .exe IMMEDIATELY goes to not responding when trying to exit.

Don't worry about it, standard behaviour unfortunately. If you find it too annoying (I do!) then you'll need to install New Vegas Script Extender and New Vegas Stutter Remover, the latter has an option to fix the issue and also makes the game run much smoother.