I love killing ghouls, the feral kind I mean. Ghoul battles are fast, frantic, and the times there are mobs of them, it reminds me of Night of the Living Dead, or "State of Decay" if you've ever played that. There was one particular battle in a little flooded village near the river to the west, where Piper and I were on a rooftop in the middle of the night, and ghouls were just coming from everywhere, and we fought back to back to keep from being overwhelmed as they climbed up to get us.
Anyway, I'd like to see a DLC in the vein of "Dead Money" from FNOV. You travel to this region, and are locked in, you cannot leave until the mission/situation is resolved. Your only assets/weapons/stimpaks/ammo/ect are what you carried with you, and what you can find in this new region. There is no quick traveling back to settlements to resupply. Ghouls would be the problem, and you would have to face mobs of them. That's the basis of my DLC idea, it would obviously need to be fleshed out by someone more creative than I.