I want to make a stealth melee build but SPECIAL points are very tight and there's just no room to take Locksmith or Hacker. Thing is I find Locksmith at least to be near-mandatory, due to the amount of containers and locked doors which lead to nice loot and new areas.
What's it like playing without either of these perks, do you feel like you're missing out? I feel like it would drive me nuts not to be able to open so many locks.