I've read that Operation Optimization is obsolete and that http://tesnexus.com/downloads/file.php?id=10400 is a better option.
http://tesnexus.com/downloads/file.php?id=23208 works well for me also.
kuertee's http://tesnexus.com/downloads/file.php?id=24606 can improve performance by keeping saves clean and preventing save game bloat.
Also, you might consider kuertee's http://tesnexus.com/downloads/file.php?id=22136, which features purge-cell buffering (like Streamline) which optimize memory usage. It's not entirely compatible with streamline though, and if you use the purge cell buffer feature (the part that enhances performance), it will be completely incompatible.
For the wilderness, some good ones are http://tesnexus.com/downloads/file.php?id=5434, http://tesnexus.com/downloads/file.php?id=15278, and http://tesnexus.com/downloads/file.php?id=2069.
As a side note, with your specs it depends a lot on what graphics settings you are using (Medium, High, etc) and how many other mods you're running. You shouldn't have too many mods running with that rig, they can bog down performance significantly. Mods that add extra scripts running in the background (most mods that add extra features and behaviors to NPCs) place a big strain on your CPU, and thus have a sneakily huge effect on overall performance, even though they do not enhance graphics in any way.