So I was riding along and encountered a thief guarding a bridge... I dismount and have a chat with her, to which the conversation goes like this:
Thief - "Hand over all your valuables or I'll gut you like a fish!!"
Me - "I don't have time for this..."
Thief - "Don't you walk away from me!!"
At that point conversation ends, and the thief then says to me, "Safe travels!" and then immediately attacks!
As I was killing her I couldn't help but bust out laughing at this. "Safe travels... HAVE AT YOU!!"

Just a little irony that made me LOL while playing.
What little ironies or goofy situations have YOU come across while playing that made you bust a gut? Post 'em here but please, no spoilers. Just general in-game stuff that happens randomly that is good for a laugh!