As in, NPC's that are supposed to come up to you and initiate the dialogue first when they see you, like Sunny when you first go into the saloon, aren't doing so. Just noticed it taking the quest from McNamara in the BoS shelter, Paladin Ramos doesn't talk first, I just walked straight passed him when he is supposed to talk first and take you to the elder. Then Hardin didn't talk when walking out after taking the quest to find the holotapes. Can't even speak to him when I click on him, he just stands there. When I got to Repconn, the Facial recognition Mr Handys just float passed, they are supposed to come up to you and check whether you're friend or foe by initiating dialogue.

Hasn't really been a problem as such (so far) and can still initiate dialogue first myself, but I shouldn't have to really. And I'm a bit worried it might affect a quest later. For example player controls are disabled when an NPC is supposed to come up to you to speak...because with this bug that won't happen and I'll be stuck. Here is my load order:

FalloutNV.esm
DeadMoney.esm
HonestHearts.esm
OldWorldBlues.esm
Project Nevada - Core.esm
Project Nevada - Equipment.esm
SuperJump_Land_5x.esp
MoMod.esm
AWorldOfPain(Preview).esm
AWOP-MoMod.esp
AWOPMonsterPatch.esp
FalloutNVQuickMessages.esp
Companion Sandbox Mode.esp
NewRecipes.esp
Casino Bypass.esp
BearTrap.esp
BoltGun.esp
WeaponModsixpanded.esp
NCR Rearmament v1.5.esp
Portable Tent.esp
BinocularsOverhaul.esp
Project Nevada - Cyberware.esp
aaaJNFSniperZooming.esp
Sprint Mod.esp
DK_BulletTime_NV.esp
Reactive People II - Sneak & Diversion.esp
Readius_NV.esp
Egg Hatchery.esp
FalloutNVCheatTerminal.esp
theHeroNV_1.1.esp
Nights are Darker 25%.esp

Those are all active. Well it's a long shot but hopefully someone will have some advice, never had this one before, thanks.

I am experiencing the same problem. Completely breaks old world blues.

Edit: I have looked into fnvedit and the geck to determine what's going on, but keep coming up empty. No clue.

Damn, and I was right. Starting Old World Blues the floating scientists won't start speaking when you first go into the room and player controls are disabled. Ugh...I don't really look forward to having to start again. But I might have to. Ffffffffffffffffff...

Edit: Posted before I saw poopoopapa's comment. Do you have any similar mod to what I'm running? Though I'm not sure if that would even get us anywhere, I took out all my mods except the DLC's and it still happened.

FalloutNV.esm
DeadMoney.esm
HonestHearts.esm
OldWorldBlues.esm
AWorldOfPain(Preview).esm
Project Nevada - Core.esm
Project Nevada - Equipment.esm
CaravanPack.esm
IWR.esm
Frequency.esm
Military NV Backpacks.esm
NVStripOpen.esm
Primary Needs HUD.esm
RH_IRONSIGHTS_NV.esm
More Challenges.esm
New Vegas Redesigned.esm
ArmourRepairKits.esp
IWS-Core.esm
More Perks.esm
More Perks for Companions.esm
More Perks for Dead Money.esm
More Traits.esm
More Perks for Honest Hearts.esm
MoMod.esm
DarNifiedUINV.esp
CASM.esp
Bobblehunt.esp
HUD Extended.esp
IWR - Rebuilt.esp
Purge Cell Buffers.esp
AWOPMonsterPatch.esp
AWOP-MoMod.esp
StripOpenNPCs.esp
NV Interiors - El Ray Motel.esp
NV Interiors - West Vegas Fringe.esp
NV Interiors - Cottonwood Cove.esp
Schoolhouse Base.esp
UHNV.esp
UHNV-Dead Money.esp
UHNV-Bobblehunt.esp
UHNV-Brighter Lighting.esp
Lucky38MarkerV3.esp
Project Nevada - Cyberware.esp
Project Nevada - Rebalance.esp
Project Nevada - Dead Money.esp
Project Nevada - Honest Hearts.esp
RNVExtended[100]v3b1.esp
Dog_City3.esp
HarderThan.esp
NewVegasBounties.esp
NewVegasBountiesII.esp
LibrarianOfTheWastes.esp
More Perks Update.esp
More Perks for Companions Update.esp
More Perks for Dead Money Update.esp
More Perks for Honest Hearts Update.esp
More Traits Update.esp
NV_STTraitsandPerks_Crunch - NVSE.esp
Frequency - Dead Money Patch.esp
Frequency - Honest Hearts Compatbility Patch.esp
AmmoCraftingSchematics.esp
BinglesMelee.esp
Classic Midwestern Power Armor.esp
Military NV Backpacks - Vendor Script Replenish.esp
Lore version.esp
KillingKarmaFix.esp
XtraSpecialNV.esp
WeaponModsixpanded.esp
Project Nevada - WMX.esp
WMX-ModernWeapons.esp
WMX-DeadMoney.esp
WMX-HonestHearts.esp
WMX-PreOrderPackCaravan.esp
Nevada Skies - URWLified.esp
DYNAVISION 2 - Dynamic Lens Effect.esp
ELECTRO-CITY - Imaginator.esp
Caravaner.esp
Meltdown Medley.esp
Bashed Patch, 0.esp

Total active plugins: 79
Total plugins: 98

Only thing i can think of is project nevada tbh. I'm kinda half-assing a look at this thread for more info, but it's on oblivion. http://www.thenexusforums.com/index.php?/topic/83234-all-golden-saints-and-dark-seducers-exhibit-i-have-no-greeting%26-3/