I don't think so. It all depends on how much people loved the game. Star Craft II is a great example. Nothing was done for 10 years and look at it now? Same for Diablo II.
Same for Oblivon. People were shocked, upset at Todd and Bethesda at E3 where there was NOT EVEN ONE MENTION of Oblivion. Look how successfull Oblivon turned out to be.
You don't need E3 to make people interested. At most 50 000 or so people attend the event? So for the rest of the millions nobody will be we bother with E3.