Salvia Divinorum leaves/extract and certain kinds of Morning Glory (Ipomoea violacea), as well as rarer Hawaiian Baby Woodrose (Argyreia nervosa) and Rivea corymbosa, are the best and safest legal ways to lose one's mind virginity
It's very sad that salvia is becoming illegal im more and more places without any bit of research to back it up, just fear mongering and moral panic, while hundreds of thousands of people use and have used it with no adverse effects. Mazatec indians used Salvia in their rituals, though they did not smoke it, but put plant material under their tongue for a milder and longer lasting effect. I can testify for anyone considering salvia (of course only if it's legal where you live, it's still federally unscheduled in the US), that be prepared for what you cannot be prepared. It throws you straight in the deep end, your reality will be shattered within seconds if you are smoking it. It's something that stays with you your whole life
Morning glory and Rivea corymbosa have been used by many indigenous peoples in latin america for many centuries if not millenia. They contain LSA, a substance chemically almost identical to LSD, though it doesn't usually produce open eye visuals (closed eye visuals are amazing though). An experience from these seeds will last up to 10 hours
There is also the Fly Agaric, or Amanita muscaria. Most people think it's a deadly mushroom, but you know what they say, most people are idiots
. If prepared right and treated with heat which turns the toxic (not deadly) ibotenic acid into the psychoactive muscimole, it's pretty harmless (naturally if you don't eat a bag of it). Tribes throughout Siberia have been using Amanita muscaria in shamanic rituals for ages, and Gordon Wasson even suggested that this mushroom is the fabled "Soma" plant.
There are other completely legal psychoactive substances but they are usually dangerous and even deadly so I won't list them here. Just a word of caution,
stay away from deliriants. These include all species of Datura, Atropa belladonna, Mandrake and Henbane, and any other Solanaceae plants that contain Atropine, Scopolamine and Hyoscyamine. Not only are those experiences very uncomfortable (horrible) for the majority of people, they are complete delirium and separation from reality, while still maintaining motor control. Which means you might be walking down a highway under the influence but you think you're actually taking a stroll along the beach. On top of that they are impossible to dose and very toxic. Seriously, just don't, a google or youtube search will result in countless news articles of teenagers dying from these plants, especially Datura. The indigenous amazonians don't call it yerba del diablo for nothing.