No, at least no to part with knuckles.
Well, not a total no at least since I think that there should be a way for us to be able to own with H2H and not use any kind of weapons, not even knuckles or gauntlets.
One way is to be able to find clothes that will improve our unarmored and unarmed abilities (for example, it will give you bonuses to H2H, strength, agility, speed and such or some stuff equal to that since I've heard that we won't be seeing attributes anymore), they will be rare and hard to get so those that depend on weapons and armor don't feel like idiots because they have to search for their stuff.
Also, there could be scrolls/tomes all over the Skyrim (more powerful ones will be more rare) witch will contain techniques of martial arts witch will basically improve your unarmored and unarmed fighting style.
You could equip them just like a weapon and will take up two slots (only one teaching at the time
), but they won't be visible on the character (maybe will only carry around the waist it or something like that) and will give you bonuses.
Also, those scrolls/tomes could also contain some secrets to arcane martial arts instead of just improving existing ones.
By that, I mean that your fists and legs would also be enchanted by fire, ice, shock and other effects that could go well with martial arts.
That way martial artists could also be a powerful sort, but still demand some gear searching.
And yeah, killing dragons with fists is PERFECTLY NORMAL FOR A FANTASY GAME!
Martial artists in real life preform feats that others can't even think of, so it would be actually much easier for them to kill one in a fantasy world.