I think the best way to get the balance and difficulty you prefer in Skyrim is to make it for yourself.
It's not just limited to difficulty setting. You can use a combination of skill builds, enchantments, perks and potions (or the omission of using these) to ensure combat is the way you prefer it.
Myself, to become a vampire necromage I level the non-combat skill restoration to seventy as soon as I leave Helgen. Enemies will far outlevel me in combat skills because of it.
This, together with the non-regenerating stats of a vampire in daylight, not using damage increasing perks, potions or enchantments and because I never put more then five level-ups in health and stamina respectively means that each combat encounter is a potentially lethal challenge until well in my level 40's and that until endgame there exist enemies that are either best avoided altogether or taken out by subterfuge, such as high level Draugr and high level dragons.
It's all about what is comfortable for the individual player and if you know the mechanics of Skyrim moderately well it's possible to create characters ranging from demi-gods to those that couldn't punch themselves out of a wet paper bag.