Actually, I consider myself to be a very serious "roleplayer," but only some of the OP's demands interest me (more the ones dealing with NPC behavior than with "realism" restrictions). In spite of the fact that many consider things like having to eat and sleep "serious roleplaying," I don't. To me, "serious roleplaying" is the act of creating a unique, detailed, complex character and "playing" that "role."
In my case, I don't really consider needing to eat, drink and sleep necessarily any more "serious" as far as roleplaying goes.
It's just that the challenge makes it more fun for me (on a personal level) when the PC suffers huge penalties or death for not eating, drinking and sleeping. After installing Harder hardcoe rates mod for FNV, I actually died from dehydration frequently, and spent most of the time running around suffering from reduced stats due to hunger, as I believe a character living in that sort of wasteland environment might actually experience. I'm going to install Arwen's Tw.eaks soon, which adds all sorts of features like, infections from wounds, disease and illness, etc.
In the case of Skyrim, it seems that deer and game will likely be plentiful, as well as fresh water from rivers and wells, but as I experienced with Oblivion after installing COBL Real Hunger, Real Thirst, Real Sleep Extended, implementing hunger, thirst and sleep functions actually give you a reason to be happy to find a small inn in the forest after hours of wandering, for example, or to find a creature with some meat. It really improved the Oblivion experience for me.
When the PC is so hungry that you need to steal some food in order to survive, it makes the game a lot more interesting for me. Of course, unless the economy system is balanced this becomes less interesting. I'm hoping either the vanilla game or some economy mod will make it extremely difficult to become rich.
It was far too easy to become rich in vanilla Oblivion, as well as FO3 and FNV.