I can't think of anything that affected me in real life. I could think of some moments that moved me emotionally. I think the end of the Main Quest was pretty moving. Also maybe the FG questline.
Well, the Purification kind of... ...
I thought the Next of Kin DB quest was pretty sad and f***ed up
I find it hard to understand how people could feel sad about killing a bunch of psycho murders that brag about killing children, but not mind killing a lady and her whole family. Or a gamblers Mother to pay off his debts. That just seem strange to me.
Corrupting that man to try and kill me to get that mace from that certain daedric prince. In real life that would be ****ed up.
One of the worst quests in the game. I don't even do that with my evil characters. I've failed the quest in a way were you can still get the Mora quest.
It's not just a corrupting that man. It's corrupting a Paladin, grieving over his dead wife in a way that makes him betray his promise to his wife.