Have you forgotten to save after a few hours?
In other games, sure, it's happened now and then. Usually doesn't bother me too much because re-doing it always takes about 1/4 the time it took me to do it the first time, but still annoying.
In NV tho, no, hasn't happened yet. The constant CTD's in the original version of the game taught me to hard-save in a new slot
constantly. Since all the patches I've mellowed out on that a little bit but I still make at least 100 saves per game...and that's (edit:
not) including saves I make for specific, non-gameplay/quest reasons (such as for testing mods, making videos, wanting a save of something particular for reference, etc). I have no auto-saves on at all, only time that happens is the few that the game forces on you at quest points. Do use quicksave a lot. Since I like to keep total saves in the Save folder kinda small, I constantly backup elsewhere with readmes and delete them from the game folder, too.
During a quest, like the Three-Card Bounty quest, I'll have many saves in sequence in case it doesn't go the way I want...like someone's head has a problem because Boone goes nutzo or having too low of a skill for a speech challenge. Then I don't have to redo hours of play and it can still be fun.
I do the same thing. I keep trying to make a perfect set of saves, with a save just before every single point in the game that I personally enjoy/might want to replay (or capture on a video), which would probably amount to at least 250 saves, haha, but so far I keep getting distracted (or a new patch comes out, or I try a mod that alters the equation) and then.... :rofl: