I finished the quest of Ed-e and sent him to the lucky 38, later picked up Rex and sent him there as well but when I went there, they were nowhere to be found. Eventually I found Rex at the Kings School in Freeside, but ED-E still missing. I'm starting to thing that the aliens abducted him, lol. Anyway, I checked the Primm and nothing. Anyone got any ideas?

The same thing happend to me, and he's gone for good. I started Dead money because I knew that sent companions back to where you first met them, but after I was done with the DLC Ed-e wasn't anywhere to be seen in Primm.

If you're on the PC there's a console command which can help you get him/it back.

If you go the Vault with all the crazy plant life and use the elevator inside, any missing companions should spawn.

Abit of knowledge here but ed-e has a stupid thing for glitching everywhere he goes, high chances if you sent him to lucky only consle commands are gonna get him back. if he goes missing while in your team, you can get him back by using the a vault elevator. The wikia might have more info on how to lose him and where to be careful

Thank you all fellas, I went to vault 22 and problems are solved.

arnt you not supposed to put any post asking for help?

I truly don't know. I've been here for only a couple days. But, I'll look into that. thanks anyway.