Something needs to be fixed on the Mothership Zeta add-on for Fallout 3. At the start of the quest "This Galaxy Ain't Big Enough" all of the following npcs come through the teleportation matrix. All of the npcs are supposed to stand in the center of the room where you can look down and see Earth. A hologram of an alien head is supposed to appear and talk. The hologram does not appear no matter what I do. The npc Sally is supposed to open the locked door in this room so I can continue on with the mission. Because of the hologram not appearing she will not open said door. Everyone stands in this center of the room and I can not progress any further. I have invested over 70 hours into my current save, so deletion is not an option. I have no saves of before the glitch happened my only save is in the room they are in. So, please if there is a fix tell me. From what I've seen I'm not the only person with this problem.

There is no fix, not for consoles anyway.

Mothership: Zeta is the second worst of gamesas's releases, when it comes to buggyness (the worst being the ancient game Daggerfall, released in the 1990's.) It's suspected that gamesas fired their then QA director because of how buggy MZ ended up being. For many people the DLC is unplayable.

If you were on a PC, you could force the next stage through console commands, or download the unofficial patch to help make MZ more... stable. As you are on console, your only options are to...

1: Restart your save.

2: Reload an earlier save.

In other words, you're SOL. If you can, try waiting and see if that causes it to occur.