I have played FPS games for longer than I care to admit. I originally ignored VATS and treated the game like any other FPS. Wow was I missing out. VATS is nearly essential for close range combat.
Pre-VATS
- Spray and Pray close range enemies (especially fast stuff like the bugs and Ghouls). Use 4x the number of rounds necessary to kill target. Heal all the unnecessary damage I took. Repeat
- Sneaky/Sniper guys at long range. Switch back to Spray once the ground guys arrive.
Post-VATS
- I have a very nice VATS Enhanced .45 Combat Rifle with max mods. I also have level 2 Action Perk and all "Ultra Lightweight" Armor. So I have a ton of AP (even back when I was only level 20-30)
- At Close Range - Load up enough shots to kill target #1. If there are 2 targets in close range I can usually load up enough damage to also kill target #2
- As soon as the critical meter is full I usually pop it if the target has greater than 50% health
- Rinse and Repeat. I usually only need to heal every 5 targets (unless there is something else going on)
- If I want to snipe, I will usually just aim manually, unless I have a couple criticals to use. Once the targets are close to my position I switch back to VATS
I usually shoot most targets in the head. But anything I need to stop quickly (like ghouls) I will take out a leg first. Once I was actually able to nearly incapacitate a Deathclaw's leg
One Regret about VATS: I wish it didn't drain the power armor so quickly. 95% of the time I will exit the power armor to fight the enemy because I'm saving the power cores.