I always play as a battle mage, and being a PS3 guy, I am very concerned about switching my spells during battle without having to interrupt my game every time. If there are two hands to assign, I'm hoping that they will use the directional pad for hot keys as they did in Oblivion, but that now we will have to assign the hot keys to a default hand. IE: Up = Left Hand Heal Spell, Right = Right Hand Destruction Spell, Down = Right Hand Sword, etc.
The problem with this is that it sort of halves the amount of hotkeys you have.
Essentially it should be:
Console: Up = Heal Spell, Right = Destruction Spell
PC: 1 = Heal Spell, 2 = Destruction Spell
Then to put the heal spell in your left hand you press:
Console: Up, Left trigger
PC: 1, Left mouse button
or for right hand:
Console: Up, Right trigger
PC: 1, Right mouse button
If you assigned a hot key per hand; then each item would take up 2 hotkeys if you want the ability for them to be in either hand...