Title says it all. I just want to clean everything up for my three main character plan.

You want to get rid of the saves?

Documents-> My Games -> FalloutNV-> Saves

Delete all the contents of the folder. (Not the folder itself, just everything inside of it)

If you want to keep the saves but clean out the in-game saves, select all of them and put them in some other folder for later use.

it worked thanks.

Alternatively, when you've got the list of saves displayed, as in loading a game, right-clicking on a save gives you the option of deleting it. I clean mine up with this method from time to time.