I only play the Sawyer mod on hardcoe, so I can't speak for the Sawyer mod on any other level; on hardcoe though, the DTs (and I believe the DRs as well) for power armor, heavy armor, and I believe medium armor as well have been markedly increased. To give you an example, they're high enough that rounds from Medicine Stick and Brush Guns will all but bounce off power armor- and they're not that much more effective against the other two types either. So unless you're a heavy weapons enthusiast, you'll need to make good use of cover when you're not actually firing when you go up against well armored opponents. Fiends are still a non- issue, as are gang members- unless you are using the Factions Reloaded mod- in which case the latter are well armored and armed. It's definitely worth trying, particularly if you are looking for a greater challenge.
Just give it a shot. If you do not like it you can always uninstall the mod and start a different character or go back to your old character.
I suggest using a new character if playing this mod, that way you can ease yourself into the mod.