LOL nice idea. I currently have about 50-70 of every drug on me at the moment, as you never know when you'll need 'em. I'll try it out in one of the Casinos. xD
I honestly don't see the point in doing this, the drugs just make your vision blurrier, maybe you'll sway a bit more, and your stats are increased / decreased based on the drug. It's kind of just saying I'll read a skill book in Guns and then destroy a highly populated city.
I mean I haven't even attempted to take drugs in this game yet but if it's anything like Fallout 3 then I don't see the point in this.
Now if it's just for the RPG aspect ( I'm high and because of this I'm killing people! ) then that's good and all, but other than that I see no point in doing this, you'll end up with the same result.