Since I'm a strong believer in narrative constructs (as expression of a greater theme, not simply a story that exists in a meaningless limbo and revolves around itself) I don't think there should be any more than 3 Vaults in or around Boston (or the whole of Massachusetts).
But it doesn't really matter at this point, since Vegas and DC already had too many Vaults, compared to the greater Core Region (LA had one Vault), which in and of itself didn't necessarily make sense from a narrative viewpoint in the first place.
So Boston having like eight Vaults (of the 122 seemingly established ones - there's no canon info on this as far as I know though, but all the designer's choices point in that direction) wouldn't really disrupt any overarching narrative, since there is none that makes any sense anyway.
Vaults are loved because the concept behind them makes for great individual experiences. And that's all really. There's nothing to suggest that you need a Vault to reach that goal. Fallout can very well work without a single Vault and it should try to focus not on the burden of enigmatic icons that streamline the narrative experience, but rather reach out for original concepts that leave the seemingly omnipresent staples behind in favor of creative freedom, unique identities and coherence at the same time.
In short: Don't ask yourself how to do Deathclaws in Fallout 5, how to make the Brotherhood unique in Fallout 5, how to justify Supermutants in Fallout 5, how to execute the Enclave in Fallout 5.
Release yourself from that burden and leave these icons behind if you don't need them, in order to strengthen the identity of your new game and the rest of the franchise.