This is half the fun for me. And the reason why one should always play through the vanilla game once or twice without any game-changing mods first.
I am really glad that I did not play through Oblivion once or twice before installing OBGEv2, ENBSeries shaders, QTP3, Tamriel NPCs Revamped, FCOM, Duke Patricks, etc.; otherwise, I would have spent 800+ hours playing a game that needed some major fixing.
I played a few hundred hours of my first playthrough with some mods like Vampire Aging Disabled, HGEC, QTP3. Then I retired that character and started a new game (my 2nd playthrough) with 150+ mods about 6 months ago. I am up around 300+ hours on that playthrough and barely at level 7.
In my experience, I can't just do a "quick runthrough" of TES games. Each playthrough lasts several hundred hours. This is way too long to spend playing a game with some problems that can easily be fixed.