I have completely stopped using health/stamina potions... and it has massively improved my game, in terms of overall immersion and making every encounter require my complete concentration.
Ordinary battles now involve a range of varied tactics which makes combat so much more exciting rather knowing I will win each one because I can heal at any time.
Also without stamina potions, getting out of breath in combat is serious business, which forces me to change tactics mid battle. Without healing items, the world becomes a lot more dangerous.. and its an awesome feeling, I havent enjoyed the game this much for a long time.
I am also making use of cooking a lot more, I now have to cook a few soups when Im in town, which involves spending some time shopping for the food items. Its akin to the micromanaging of Morrowind and is a nice change of pace from constant action. Its amazing how valuable a red apple becomes when its your sole remaining healing item. No healing potions FTW!