My last save says 175 hours and I've had two crashes in that time.
Both times they happened after I had minimized Fallout 4 and looked something up on Youtube on my PS4 and then brought Fallout 4 back up to continue playing. The crashes occurred a few minutes after bringing Fallout 4 back up while in the middle of gameplay (Not saving or exiting).
System:
PS4 w/external cooling system.
Fallout 4 (Disc Version)