The other day I read two good tweaks for speeding up the mouse. One was to remove the blur from the background when you go to the menu/inventory. I think it involved modifying an ini file. There was also another tweak they mentioned with this but I can't remember what it was :/
if its depth of field you mean , you should be able to go to skyrimPrefs.ini in documents/ my games / skyrim. and set bDoDepthoffield to 0 and save it.
You need to add this to Skyrim.ini (not SkyrimPrefs.ini)
[Imagespace]bDoDepthOfField=0bDoRadialBlur=0
Depth of Field = Unsharp surroundings during dialogue. Radial Blur = Circular blurring of the background in menu mode
Nice, but those two parameters were already in my Skyrimprefs.ini and they were already set to 0. I added them to Skyrim.ini at the end and set them both to read only. Hopefully I won't have this problem again.