End?
The west coast storyline had their whole Unity, Enclave, NCR, Legion thing going on with them.
So it could be possible for that story to tie itself up.
But now it's split into three sides.
Western storyline, 3 games.
Mid-western storyline, 1 game.
Eastern storyline, 1 game.
So an "ending"?
I don't think it's possible for Fallout to ever have an "ending" ending.
A storyline from a game might tie itself up but there is no actual story connecting the games.
Just the Fallout universe.
And that universe simply cannot end unless an evil ending which includes killing every single living organism on the planet is the canon ending.