I've been playing this game on a high end PC since launch. I've gone through the various bugs - as have most people - and I'm running the DX9.dll fix and community patch; both made the game considerably more stable and playable.

My problem is that after many, many, many hours of playing on my second run through the Mormon Fort and Crimson Caravan both crash as I try to enter those areas.

Freeside to Mojave - loads fine
Mojave to Gun Runners factory - loads fine
Gun Runners Factory to Mojave - loads fine
Mojave to Crimson Caravan - loads, loads, loads .... BARF CTD

Freeside to Mormon Fort? loads, loads, loads ... BARF CTD

I've run the steam checker to ensure my local files are good, tested different save points, NOT even touched the dreaded Come Fly With Me ... I've been into both locations tens of times with this level 12 character, so why would these two now start barfing?

Corrupted spawns is possible.

Turn off saves on interior/exterior transitions (if it still exists...the option is in the INI, but I don't recall it in the game).

Make sure you have a good save to come back to. Leave the area and wait four or five days. Return and try to enter the areas again. Should reset the spawns which will likely eliminate the possibility of a corrupted/badly placed spawn.