There are a number of initiatives I'd create:
1. Containment and Eradication squads: these would be top hunters/rangers employed to ensure that 'pest' hotspots firstly don't continue to grow and slowly, over a period of several years, would kill them off until any infestations of Deathclaws, Cazadores or other such creatures are gone or at least contained.
2. Prospector and scavenger teams: these people would be employed to help find scrap material useful to the NCR and New Vegas in any shape or form.
I would improve the slums around Freeside by creating some industry to employ people in that would also help the Mojave as a whole, one example would be to create a textiles factory as clothing is a necessity and many wastelanders seem to be lacking in that. I would also continue relations with the King to either accept NCR rule but allow the gang to still exist or incorporate him into the NCR and be put in charge.
The Strip itself seems to be draining the NCR of much funding so I would open the Lucky 38 (now that House is gone) as an NCR-owned casino and heavily tax any other ones. All soldiers employed by the NCR are allowed to gamble but there will be limits to how much they can gamble away.
I would create more peace across the Mojave by placing one NCR ranger or high level officer in each town to act as a sheriff, even if they don't want NCR rule (the sheriff can just help out). I would also create a radio system for every town so they can communicate and get help quicker.
Jacobstown would be protected and promoted as a refuge for Super Mutants; however, to prevent them becoming isolated and aid in integration I will encourage them to venture out into the wasteland more for good aid (as troops namely).
I would establish bases on the Western side of the dam just to protect from any potential move from the Legion and push the frontline slightly forward.
The Followers of the Apocalypse would get some further funding to help them and hopefully expand their size.
Finally, to improve trade routes I would start an initiative to repair or create roads all across the Mojave so carts, possibly cars and other transport can begin to exist.