Yes, 100%. Everything being done is in interiors so it doesn't interfere with the outside. Though the layouts won't match for OCR cities. OCC cities will be fine.
Active Mod Files:00 Oblivion.esm01 Jog_X_Mod.esm02 All Natural Base.esm [Version 1.0]03 Cobl Main.esm [Version 1.72]04 Qarls_Harvest.esm05 CyrodiilUpgradeResourcePack.esm06 Better Cities Resources.esm07 BetterMusicSystem.esm08 BathingMod_Base.esm09 CURP_Controller.esm0A AFC v2 Core.esm0B Progress.esm [Version 2.2]0C A_Bloody_Mess.esm0D HorseCombatMaster.esm++ HrmnsOblivionScriptOptimizationv1.0.esp0E Unofficial Oblivion Patch.esp [Version 3.3]0F Oblivion Citadel Door Fix.esp10 DLCShiveringIsles.esp11 Immersive Interiors - Lights Addon.esp----> Delinquent MASTER: Immersive Interiors.esp12 Unofficial Shivering Isles Patch.esp [Version 1.4.0]13 All Natural - Real Lights.esp [Version 1.0]14 All Natural.esp [Version 1.0]15 All Natural - SI.esp [Version 1.0]16 Immersive Interiors.esp++ Symphony of Violence.esp17 AmbientTownSounds.esp18 Distant Chapel Bells.esp19 Diverse Voices.esp [Version 0.1a]1A Rainbows.esp1B Cities Alive At Night.esp1C WindowLightingSystem.esp1D 300_Lore_Dialogue_Updated.esp1E AFC v2 Combo Chains.esp1F AFC v2 Combat Moves.esp20 AFC v2 Quick Powerattacks.esp21 AFC v2 Damage Text.esp22 AFC v2 Gauntlet Weaponry.esp23 AFC v2 Locational Damage.esp24 BookTrackerOBSE.esp25 Cats & Rats.esp26 VanityCameraSmoother.esp27 ClocksOfCyrodiil.esp28 Fishing in Cyrodiil.esp29 ImprovedSigns.esp2A MM_TextLocks.esp2B P1DseeYouSleep.esp2C Portable Campsite.esp++ P1DseeYouSleep - Portable Campsite.esp2D Q - More and Moldy Ingredients v1.1.esp2E Qarls_Harvest.esp2F Qarls_Harvest addon.esp30 Willful Resistance.esp [Version 4.0]31 Wyverex - Deployable Traps.esp32 Enhanced Economy.esp [Version 4.3]33 Crowded Roads Revisited.esp [Version 1.1]34 Crowded Roads Revisited_ChorrolCheydinhal_5.esp35 Crowded Roads Revisited_GreenRoad_10.esp36 Crowded Roads Revisited_YellowRoad_10.esp37 Crowded Roads Revisited_GoldRoad_20.esp38 FF_Real_Thirst.esp39 Choices and Consequences.esp [Version 2.1]3A Map Marker Overhaul.esp [Version 3.6]3B Map Marker Overhaul - SI additions.esp [Version 3.5]3C Improved Hotkeys_Extended.esp [Version 1.1]3D DLCHorseArmor.esp3E DLCHorseArmor - Unofficial Patch.esp [Version 1.0.5]3F DLCOrrery.esp40 DLCOrrery - Unofficial Patch.esp [Version 1.0.3]41 DLCVileLair.esp42 DLCVileLair - Unofficial Patch.esp [Version 1.0.5]43 P1DseeYouSleep - DLCVileLair.esp44 DLCMehrunesRazor.esp45 DLCMehrunesRazor - Unofficial Patch.esp [Version 1.0.4]46 DLCSpellTomes.esp++ DLCSpellTomes - Unofficial Patch.esp [Version 1.0.1]++ MaleBodyReplacerV4.esp47 ACCCGR SI.esp48 WarriorBandages_V2.0.esp49 Thieves Arsenal.esp++ Thieves_Arsenal_Patch_033010.esp4A Extinguish the Lights.esp4B DLCThievesDen.esp4C DLCThievesDen - Unofficial Patch.esp [Version 1.0.5]4D DLCThievesDen - Unofficial Patch - SSSB.esp [Version 1.0.4]4E Cobl Glue.esp [Version 1.72]4F Cobl Si.esp [Version 1.63]50 FF_Real_Thirst, Cobl.esp++ Cobl Tweaks.esp [Version 1.44]51 Bob's Armory Oblivion.esp52 Creatures Alive v1.3.esp53 kuerteeWanderingEncounters.esp54 TIE.esp [Version 1.36]55 Lock Bash Omega.esp [Version 1.5]56 Duke Patricks - Bottle Shoot Archery Practice.esp57 Extended Imperial City Version 1.0.esp58 FuseFruitMachine.esp [Version 1.0]59 FuseSnailRacing.esp5A Kragenir's Death Quest.esp5B KDQ - Rural Line Additions.esp5C Corpse_Kvatch.esp5D LetThePeopleDrink.esp [Version 2.5]5E KragenirsDeathQuest-LetThePeopleDrink patch.esp5F Region Revive - Lake Rumare.esp60 TheElderCouncil.esp61 TheElderCouncil_TempleOfTheOne.esp62 TEC_4ERA_Dialog_Filter.esp63 thievery.esp64 thievery - EE patch.esp [Version 4.2]65 Travelers Inns.esp66 VaultsofCyrodiil.esp67 Window Entrances 1.0.esp68 za_bankmod.esp69 DLCBattlehornCastle.esp6A DLCBattlehornCastle - Unofficial Patch.esp [Version 1.0.4]6B Lynges_Thieves_Highway-10256.esp6C DLCFrostcrag.esp6D DLCFrostcrag - Unofficial Patch.esp [Version 1.0.4]6E Knights.esp6F Knights - Unofficial Patch.esp [Version 1.0.9]70 SM Plugin Refurbish(Merged).esp [Version 1.30]71 Choices and Consequences - SM Plugin Refurbish - Orrery.esp [Version 2.0]72 ElsweyrAnequina.esp73 road+bridges.esp [Version 4.5.7]74 Feldscar.esp [Version 1.0.4]75 Vergayun.esp [Version 1.0.5]76 Faregyl.esp [Version 1.0.10]77 Faregyl+Anequina Patch.esp78 xuldarkforest.esp [Version 1.0.5]79 xulStendarrValley.esp [Version 1.2.2]7A xulTheHeath.esp7B XulEntiusGorge.esp7C xulFallenleafEverglade.esp [Version 1.3.1]7D xulColovianHighlands_EV.esp [Version 1.2.1]7E xulChorrolHinterland.esp [Version 1.2.2]7F xulBeachesOfCyrodiilLostCoast.esp [Version 1.6.4]80 xulBravilBarrowfields.esp [Version 1.3.2]81 xulLushWoodlands.esp [Version 1.3]82 xulAncientYews.esp [Version 1.4.3]83 xulAncientRedwoods.esp [Version 1.6]84 xulCloudtopMountains.esp [Version 1.0.3]85 xulArriusCreek.esp [Version 1.1.3]86 xulPatch_AY_AC.esp [Version 1.1]87 xulRollingHills_EV.esp [Version 1.3.2]88 xulPantherRiver.esp89 xulRiverEthe.esp [Version 1.0.2]8A xulBrenaRiverRavine.esp [Version 1.0.2]8B xulImperialIsle.esp [Version 1.6.5]8C Fuses Snail Racing Unique Landscapes Imperial Isle patch.esp8D RegionReviveLakeRumare-ImperialIsle patch.esp [Version 1.3.3]8E xulBlackwoodForest.esp [Version 1.0.4]8F xulCheydinhalFalls.esp [Version 1.0.1]90 xulAspenWood.esp [Version 1.0.2]91 xulSkingradOutskirts.esp92 xulSnowdale.esp [Version 1.0]93 NRB4+UL-II+LtPD Patch.esp [Version 3.0.1]94 NRB4+RR Patch.esp [Version 2.1]95 Harvest [Flora].esp [Version 3.0.0]++ Harvest [Flora] - Shivering Isles.esp [Version 3.0.0]++ Harvest [Flora] - DLCVileLair.esp [Version 3.0.0]96 Harvest [Flora] - DLCFrostcrag.esp [Version 3.0.0]97 CoverYourself.esp98 DropLitTorchOBSE.esp [Version 2.4]99 DS Storage Sacks.esp [Version 1.21]9A Dungeon Actors Have Torches 1.6 CT.esp9B Exterior Actors Have Torches 1.3 CT.esp9C gardening.esp9D GP_Lockpicks.esp [Version 1.5]9E HelmetFOV.esp++ Hurt Me Bad Traps.esp9F ImprovedSoulgems.esp [Version 1.11]A0 kuerteeInventoryIsABackpack.esp++ GotNoClass.espA1 P1DkeyChain.esp [Version 5.00]A2 PersuasionOverhaul.esp [Version 1.43]A3 ReneerNPCNameMod.espA4 RenCorpseMod.espA5 kuerteeGoldIsAnInventoryItem.espA6 Salmo the Baker, Cobl.esp [Version 3.08]A7 SetsunaDummyTraining.espA8 Enhanced Vegetation [110%].espA9 talkwithyourhands2.espAA Toggleable Quantity Prompt.esp [Version 3.1.1]AB kuerteeAlternativesToDeathAndReload.espAC Enhanced Economy - House prices.esp [Version 1.0]AD Alternate Start Revamped.espAE BathingMod_Soap.espAF BathingMod_Bathroom_Upgrades.espB0 BathingMod_Placeable_Bathtubs.esp++ BathingMod_ABMCP_Bathtubs_and_Bathrooms.espB1 RealisticFatigue.espB2 RealisticHealth.espB3 Real Injury.espB4 RealisticForceMedium.espB5 ReneerKeyLockMod.espB6 RealSleepExtended.esp [Version 2.4.2]B7 Duke Patricks - Basic Hypothermia.esp [Version 3.1]B8 Duke Patricks - Nosferatu Class Vampires.esp [Version y]B9 RefScope.esp [Version 2.0.2]BA Syc_AtHomeAlchemy.espBB RshAlchemy.espBC RshAlchemyRecipes.espBD StealthOverhaul.espBE StealthOverhaul, Cobl.esp [Version 1.2]BF SM Bounty.esp [Version 1.22c]++ CoblDeathFix.esp [Version 1.20]C0 sycSHOUT.esp [Version 1.02]C1 kuerteeClothingMatters.espC2 kuerteeCrimeHasWitnesses.espC3 kuerteeLootingDeadGuardsIsStealing.espC4 Enhanced Grabbing.esp [Version 0.5]C5 Duke Patricks - Double Arrow Nock Shot.esp [Version 1.5.1a]C6 Deadly Reflex 5 - Timed Block with no damage or durability changes.espC7 DeadlyReflex 5 - Combat Moves.espC8 Deadly Reflex Bow Sway.espC9 Deadly Reflex - Breathing Motion & Head Bobbing.espCA Duke Patricks - Near Miss Magic And Arrows Alert The Target.esp [Version 7.1]CB Duke Patricks - Actors Can Miss Now.espCC Duke Patricks - Fresh Kills Now Alert The NPCs.esp [Version 4]CD MM_AlchemyPotions.espCE BFG's Enhanced Armory.espCF Intelligence Overhaul.espD0 nGCD.esp++ nGCD Skeleton Key.espD1 ProgressGSD.esp [Version 2.0]D2 ProgressMBSP.esp [Version 2.0]D3 ProgressSBSP.esp [Version 1.0]D4 ProgressRBSP.esp [Version 1.0]D5 ProgressRacial.espD6 ProgressArmorer.esp [Version 1.0]D7 immersive_caves_auto.esp** Let There Be Darkness - Cyrodiil + SI.esp** Let There Be Darkness - Knights.esp** Let There Be Darkness - Mehrunes Razor.esp** Let There Be Darkness - Thieves Den.esp** Let There Be Darkness - The Elder Council.esp** Let There Be Darkness - Thievery.esp** Let There Be Darkness - Elsweyr.esp** Let There Be Darkness - UL Colovian Highlands.esp** Let There Be Darkness - UL Lost Coast.esp** Let There Be Darkness - UL Brena.esp** Let There Be Darkness - UL Blackwood Forest.espD8 Stat Restore.espD9 Cobl Races.esp [Version 1.52]DA MM_TextLoading.espDB MM_TrainingCost2.espDC Really Immersive Messages.espDD Get Wet - just droplets.esp** Enhanced Economy - Soulgems.esp [Version 4.2.2]DE Real Hunger, Cobl.esp [Version 1.6.1]** NRB4 Standard Road Record.esp++ Cobl Filter Late MERGE ONLY.esp [Version 1.53]DF Oblivion Graphics Extender Support.esp [Version 0.2]** All Natural - Indoor Weather Filter For Mods.esp [Version 1.0]E0 Region_Revive_-_Lake_Rumare_FuseSnailRacing_Patch.espE1 Cyrodiil Training Center.espE2 MagicDefence.espE3 ExperienceBasedTraining.espE4 LandMagicPatch.espE5 Bashed Patch, 0.espE6 Colored Map for Elsweyr 1.1.espE7 Streamline 3.1.esp