I'd try this:
Majors: Restoration, Destruction, Alchemy, Heavy Armor, Longblade
Minors: Enchant, Mercantile, Speechcraft, Armorer, Blunt or Marksman
Combat specialty with strength and endurance (for Lady sign) or agility (for Atronach)
Lady would be best sign except for the fact that an Imperial gets no magicka boost and you'll have a hard time using Destruction effectively so
maybe Atronach would better here. It's a pain to deal with but you'll have a sword and armor for fall back on if you run out of magicka and naturally, as a good
Imperial Cultist, you'll have an amulet of Divine intervention to get to a magicka filling altar.